Assessment of myocardial function and perfusion in a canine model of non-occlusive coronary artery stenosis using fast magnetic resonance imaging.

Details

Serval ID
serval:BIB_528E060549BE
Type
Article: article from journal or magazin.
Collection
Publications
Title
Assessment of myocardial function and perfusion in a canine model of non-occlusive coronary artery stenosis using fast magnetic resonance imaging.
Journal
Journal of Magnetic Resonance Imaging
Author(s)
Schwitter J., Saeed M., Wendland M.F., Sakuma H., Bremerich J., Canet E., Higgins C.B.
ISSN
1053-1807 (Print)
ISSN-L
1053-1807
Publication state
Published
Issued date
1999
Volume
9
Number
1
Pages
101-110
Language
english
Abstract
Magnetic resonance (MR) functional and perfusion imaging were employed in a canine model of coronary artery stenosis (n = 6) for the quantification of functional and perfusion deficits before and after dipyridamole administration. Left anterior descending and circumflex (LCX) coronary blood flow were measured continuously after placing Doppler flowmeters. Inversion recovery gradient echo images during the transit of MR contrast medium gadolinium-benzyloxypropionictetraacetate dimeglumine (Gd-BOPTA/Dimeg) and fast breath-hold cine MR images were acquired at baseline, during LCX stenosis in basal state, and during LCX stenosis with vasodilation (dipyridamole 0.5 mg/kg). The extent of the functional defect and perfusion defect was expressed as percent of left ventricle (LV) circumference. During stenosis (LCX flow: 62.6 +/- 5.6% of baseline) the extent of the functional defect was slightly larger than the perfusion defect (11.0 +/- 1.8% versus 6.3 +/- 1.70% of LV circumference, respectively; P < 0.01). During vasodilation the extent of the functional defect was considerably smaller than the perfusion defect (25.3 +/- 2.5% versus 35.3 +/- 3.5%; P < 0.01). Thus, the sizes of ischemic regions displayed by MR perfusion defect and functional defect differ from each other.
Keywords
Animals, Contrast Media, Coronary Circulation/physiology, Coronary Disease/diagnosis, Dipyridamole/diagnostic use, Dogs, Gadolinium/diagnostic use, Magnetic Resonance Imaging/methods, Meglumine/analogs & derivatives, Meglumine/diagnostic use, Myocardial Contraction/physiology, Myocardial Ischemia/diagnosis, Myocardium/pathology, Organometallic Compounds/diagnostic use, Vasodilator Agents/diagnostic use, Ventricular Function, Left/physiology
Pubmed
Web of science
Create date
07/09/2011 18:20
Last modification date
20/08/2019 14:07
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