The biochemistry of drug metabolism--an introduction: part 4. reactions of conjugation and their enzymes.

Details

Serval ID
serval:BIB_523BB0F76E6E
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
The biochemistry of drug metabolism--an introduction: part 4. reactions of conjugation and their enzymes.
Journal
Chemistry & Biodiversity
Author(s)
Testa B., Krämer S.D.
ISSN
1612-1880
Publication state
Published
Issued date
2008
Volume
5
Number
11
Pages
2171-336
Language
english
Abstract
This review continues a general presentation of the metabolism of drugs and other xenobiotics begun in three recent issues of Chemistry & Biodiversity. The present Part is dedicated to reactions of conjugation, namely methylation, sulfonation, and phosphorylation, glucuronidation and other glycosidations, acetylation and other acylations, the formation and fate of coenzyme A conjugates, glutathione conjugation, and the reaction of amines with carbonyl compounds. It presents the many transferases involved, their nomenclature, relevant biochemical properties, catalytic mechanisms, and the reactions they catalyze. Nonenzymatic reactions, mainly of glutathione conjugation, also receive due attention. A number of medicinally, environmentally, and toxicologically relevant examples are presented and discussed.
Keywords
Acetylation, Coenzyme A, Glucuronosyltransferase, Glutathione Transferase, Humans, Methylation, Pharmaceutical Preparations, Phosphorylation, Xenobiotics
Pubmed
Create date
21/01/2009 16:13
Last modification date
20/08/2019 15:07
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