Specific inhibition of the JNK pathway promotes locomotor recovery and neuroprotection after mouse spinal cord injury.

Details

Serval ID
serval:BIB_520C186F82FE
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Specific inhibition of the JNK pathway promotes locomotor recovery and neuroprotection after mouse spinal cord injury.
Journal
Neurobiology of Disease
Author(s)
Repici M., Chen X., Morel M.P., Doulazmi M., Sclip A., Cannaya V., Veglianese P., Kraftsik R., Mariani J., Borsello T., Dusart I.
ISSN
1095-953X (Electronic)
ISSN-L
0969-9961
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
46
Number
3
Pages
710-721
Language
english
Abstract
Limiting the development of secondary damage represents one of the major goals of neuroprotective therapies after spinal cord injury. Here, we demonstrate that specific JNK inhibition via a single intraperitoneal injection of the cell permeable peptide D-JNKI1 6h after lesion improves locomotor recovery assessed by both the footprint and the BMS tests up to 4 months post-injury in mice. JNK inhibition prevents c-jun phosphorylation and caspase-3 cleavage, has neuroprotective effects and results in an increased sparing of white matter at the lesion site. Lastly, D-JNKI1 treated animals show a lower increase of erythrocyte extravasation and blood brain barrier permeability, thus indicating protection of the vascular system. In total, these results clearly point out JNK inhibition as a promising neuroprotective strategy for preventing the evolution of secondary damage after spinal cord injury.
Keywords
JNK, c-jun, Caspase-3, Spinal cord injury, Neuroprotection, Locomotor recovery
Pubmed
Web of science
Create date
23/05/2012 11:50
Last modification date
20/08/2019 15:07
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