Unraveling the complex metabolic nature of astrocytes.

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State: Public
Version: Final published version
Serval ID
serval:BIB_51D493E006CB
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Unraveling the complex metabolic nature of astrocytes.
Journal
Frontiers in Cellular Neuroscience
Author(s)
Bouzier-Sore A.K., Pellerin L.
ISSN
1662-5102 (Print)
ISSN-L
1662-5102
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
7
Pages
179
Language
english
Abstract
Since the initial description of astrocytes by neuroanatomists of the nineteenth century, a critical metabolic role for these cells has been suggested in the central nervous system. Nonetheless, it took several technological and conceptual advances over many years before we could start to understand how they fulfill such a role. One of the important and early recognized metabolic function of astrocytes concerns the reuptake and recycling of the neurotransmitter glutamate. But the description of this initial property will be followed by several others including an implication in the supply of energetic substrates to neurons. Indeed, despite the fact that like most eukaryotic non-proliferative cells, astrocytes rely on oxidative metabolism for energy production, they exhibit a prominent aerobic glycolysis capacity. Moreover, this unusual metabolic feature was found to be modulated by glutamatergic activity constituting the initial step of the neurometabolic coupling mechanism. Several approaches, including biochemical measurements in cultured cells, genetic screening, dynamic cell imaging, nuclear magnetic resonance spectroscopy and mathematical modeling, have provided further insights into the intrinsic characteristics giving rise to these key features of astrocytes. This review will provide an account of the different results obtained over several decades that contributed to unravel the complex metabolic nature of astrocytes that make this cell type unique.
Pubmed
Web of science
Open Access
Yes
Create date
02/11/2013 21:31
Last modification date
20/08/2019 14:07
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