Stem-cell-like T cells have a specific entry gate to the tumor.

Details

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State: Public
Version: Author's accepted manuscript
License: Not specified
Serval ID
serval:BIB_51451730613C
Type
Article: article from journal or magazin.
Publication sub-type
Letter (letter): Communication to the publisher.
Collection
Publications
Institution
Title
Stem-cell-like T cells have a specific entry gate to the tumor.
Journal
Cancer cell
Author(s)
Held W., Luther S.A., Petrova T.V.
ISSN
1878-3686 (Electronic)
ISSN-L
1535-6108
Publication state
Published
Issued date
14/03/2022
Peer-reviewed
Oui
Volume
40
Number
3
Pages
243-245
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Comment
Publication Status: ppublish
Abstract
Tumor-infiltrated T cells with stem-cell-like properties are important for determining the immunotherapy response. In this issue of Cancer Cell, Asrir and colleagues show that their entry requires specialized tumor-associated endothelial cells that resemble immature and inflamed lymph node vessels and that immunotherapy enhances the recruitment capacity of these endothelial cells.
Keywords
CTLA-4 Antigen, Endothelial Cells, Humans, Immunotherapy, Lymph Nodes/pathology, Lymphocytes, Neoplasms/pathology, Neoplasms/therapy, Programmed Cell Death 1 Receptor, T-Lymphocytes/pathology, Venules/pathology
Pubmed
Web of science
Open Access
Yes
Create date
01/03/2022 12:38
Last modification date
17/05/2022 6:36
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