Serum albumin is an early predictor of complications after liver surgery.

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Version: Final published version
License: Not specified
Serval ID
serval:BIB_50E74DED136A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Serum albumin is an early predictor of complications after liver surgery.
Journal
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Author(s)
Labgaa I., Joliat G.R., Demartines N., Hübner M.
ISSN
1878-3562 (Electronic)
ISSN-L
1590-8658
Publication state
Published
Issued date
05/2016
Peer-reviewed
Oui
Volume
48
Number
5
Pages
559-561
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
The morbidity associated with liver surgery remained substantially high despite considerable surgical and anesthetic improvements. The unmet need of accurate biomarkers to predict postoperative complications is widely accepted.
This pilot study aimed to assess serum albumin as a surrogate marker of surgical stress and to test its potential predictive role for postoperative complications.
This retrospective pilot study included 106 patients who underwent liver surgery between 2010 and 2014. Serum albumin levels were measured pre- and post-operatively. Maximal albumin decrease (AlbΔmin) was correlated with complications.
Serum albumin rapidly dropped after surgery. AlbΔmin was significantly increased in patients with complications (14.5±6.0g/L vs. 10.3±7.2, p=0.009). On multivariate analysis, ASA III/IV (p=0.016) and AlbΔmin (p=0.037) were the only predictors of overall complications.
Early postoperative drop of serum albumin reflects the intensity of the surgical stress and may predict complications after liver surgery. Serum albumin is a biomarker displaying precious features and deserving further prospective investigations.
Keywords
Aged, Biomarkers/blood, Female, Humans, Liver/surgery, Male, Middle Aged, Pilot Projects, Postoperative Complications/blood, Predictive Value of Tests, Retrospective Studies, Serum Albumin/metabolism, Stress, Physiological
Pubmed
Open Access
Yes
Create date
01/05/2016 17:28
Last modification date
08/02/2022 8:09
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