T cell fate specification and alphabeta/gammadelta lineage commitment.

Details

Serval ID
serval:BIB_508F04692BC0
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
T cell fate specification and alphabeta/gammadelta lineage commitment.
Journal
Current opinion in immunology
Author(s)
MacDonald H.R., Radtke F., Wilson A.
ISSN
0952-7915
Publication state
Published
Issued date
2001
Peer-reviewed
Oui
Volume
13
Number
2
Pages
219-224
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
The development of T cells from pluripotent stem cells involves a coordinated series of lineage-commitment steps. Common lymphoid precursors in the fetal liver or adult bone marrow must first choose between a T, B or NK cell fate. Committed T cell precursors in the thymus then differentiate into cells committed to the alphabeta or gammadelta lineages. Recent advances have been made in our understanding of the mechanisms underlying T cell fate specification and alphabeta/gammadelta lineage divergence.
Keywords
Animals, Cell Differentiation, Cell Lineage, Dendritic Cells/cytology, Dendritic Cells/immunology, Digestive System/cytology, Digestive System/immunology, Humans, Killer Cells, Natural/cytology, Killer Cells, Natural/immunology, Receptors, Antigen, T-Cell, alpha-beta/metabolism, Receptors, Antigen, T-Cell, gamma-delta/metabolism, Stem Cells/cytology, Stem Cells/immunology, T-Lymphocytes/cytology, T-Lymphocytes/immunology
Pubmed
Web of science
Create date
28/01/2008 12:39
Last modification date
20/08/2019 15:06
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