Confounding factors and genetic polymorphism in the evaluation of individual steroid profiling

Details

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State: Public
Version: author
Serval ID
serval:BIB_507DAA8A3E00
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Confounding factors and genetic polymorphism in the evaluation of individual steroid profiling
Journal
British Journal of Sports Medicine
Author(s)
Kuuranne T., Saugy M., Baume N.
ISSN
1473-0480 (Electronic)
ISSN-L
0306-3674
Publication state
Published
Issued date
2014
Volume
48
Number
10
Pages
848-855
Language
english
Notes
Publication types: Journal Article pdf: Review
Abstract
In the fight against doping, steroid profiling is a powerful tool to detect drug misuse with endogenous anabolic androgenic steroids. To establish sensitive and reliable models, the factors influencing profiling should be recognised. We performed an extensive literature review of the multiple factors that could influence the quantitative levels and ratios of endogenous steroids in urine matrix. For a comprehensive and scientific evaluation of the urinary steroid profile, it is necessary to define the target analytes as well as testosterone metabolism. The two main confounding factors, that is, endogenous and exogenous factors, are detailed to show the complex process of quantifying the steroid profile within WADA-accredited laboratories. Technical aspects are also discussed as they could have a significant impact on the steroid profile, and thus the steroid module of the athlete biological passport (ABP). The different factors impacting the major components of the steroid profile must be understood to ensure scientifically sound interpretation through the Bayesian model of the ABP. Not only should the statistical data be considered but also the experts in the field must be consulted for successful implementation of the steroidal module.
Keywords
Doping, Steroids
Pubmed
Web of science
Open Access
Yes
Create date
28/04/2014 13:14
Last modification date
20/08/2019 15:06
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