Long-term calcineurin inhibition and magnesium balance after renal transplantation

Details

Serval ID
serval:BIB_50445802768E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Long-term calcineurin inhibition and magnesium balance after renal transplantation
Journal
Transplant International
Author(s)
Mazzola  B. L., Vannini  S. D., Truttmann  A. C., von Vigier  R. O., Wermuth  B., Ferrari  P., Bianchetti  M. G.
ISSN
0934-0874 (Print)
Publication state
Published
Issued date
02/2003
Volume
16
Number
2
Pages
76-81
Notes
Journal Article --- Old month value: Feb
Abstract
Regulation of magnesium balance is achieved by a steady-state mechanism in which intake and output are maintained at an equal level. Dietary magnesium intake, total and ionized plasma magnesium levels, and urinary magnesium were assessed in 46 renal transplant recipients treated with cyclosporine, nine transplant recipients who had never been on cyclosporine, and 31 healthy volunteers. Dietary magnesium intake [13.5 (11.0-15.1) mmol/day vs 13.0 (11.1-16.0) mmol/day and 13.7 (11.4-16.7) mmol/day, respectively; median and interquartile range] and urinary magnesium excretion [4.31 (3.57-5.89) vs 4.39 (3.56-6.02) and 5.01 (3.73-6.01) mmol/day, respectively] were similar in renal transplant recipients treated with cyclosporine, transplant recipients who had never been on cyclosporine, and control subjects. Total [0.74 (0.70-0.78) vs 0.80 (0.74-0.84) and 0.81 (0.79-0.87) mmol/l), respectively] and ionized [0.49 (0.46-0.52) vs 0.53 (0.50-0.58) and 0.54 (0.52-0.59) mmol/l, respectively] plasma magnesium were significantly lower in renal transplant recipients on cyclosporine than in transplant recipients without cyclosporine, and healthy controls. These observations indicate a modified magnesium steady state in renal transplant recipients treated with cyclosporine.
Keywords
Adolescent Adult Aged Calcineurin/*antagonists & inhibitors Cyclosporine/*administration & dosage Enzyme Inhibitors/*administration & dosage Female Homeostasis Humans Kidney Diseases/*blood/surgery/urine *Kidney Transplantation Magnesium/*blood/urine Male Middle Aged Postoperative Complications/blood/urine
Pubmed
Web of science
Create date
28/01/2008 13:50
Last modification date
20/08/2019 14:06
Usage data