Healing of Old World cutaneous leishmaniasis in travelers treated with fluconazole: drug effect or spontaneous evolution?

Details

Serval ID
serval:BIB_503C4CC5C659
Type
Article: article from journal or magazin.
Collection
Publications
Title
Healing of Old World cutaneous leishmaniasis in travelers treated with fluconazole: drug effect or spontaneous evolution?
Journal
American Journal of Tropical Medicine and Hygiène
Author(s)
Morizot  G., Delgiudice  P., Caumes  E., Laffitte  E., Marty  P., Dupuy  A., Sarfati  C., Hadj-Rabia  S., Darie  H., AS  L. E. Guern, Salah  A. B., Pratlong  F., Dedet  J. P., Grogl  M., Buffet  P. A.
ISSN
0002-9637 (Print)
Publication state
Published
Issued date
01/2007
Volume
76
Number
1
Pages
48-52
Notes
Clinical Trial
Journal Article --- Old month value: Jan
Abstract
The efficacy of fluconazole was evaluated in 35 travelers with parasitologically proven imported Old World cutaneous leishmaniasis (CL). Leishmania major (mainly MON-25) was identified in 15 patients and strongly suspected given the transmission area in 12 of these patients. Daily oral fluconazole (200 mg/day for adults and 2.5 mg/kg/day for children) was prescribed for six weeks. Outcome definition was based on re-epithelialization rate at day 50. Of the 27 L. major-infected patients, 12 (44.4%) were cured. This cure rate is similar to the placebo cure rate from trials in L. major CL in which, as in the present report, the definition of outcome relied exclusively on re-epithelialization. These data question the assumption that oral fluconazole is consistently effective for treatment of CL caused by L. major.
Keywords
Adult Aged Aged, 80 and over Animals Antiparasitic Agents/adverse effects/*therapeutic use Child Child, Preschool *Evolution Female Fluconazole/adverse effects/*therapeutic use Humans Infant Leishmania/drug effects Leishmaniasis, Cutaneous/*drug therapy Male Middle Aged *Travel
Pubmed
Web of science
Create date
25/01/2008 16:41
Last modification date
20/08/2019 14:06
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