Healing of Old World cutaneous leishmaniasis in travelers treated with fluconazole: drug effect or spontaneous evolution?

Détails

ID Serval
serval:BIB_503C4CC5C659
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Healing of Old World cutaneous leishmaniasis in travelers treated with fluconazole: drug effect or spontaneous evolution?
Périodique
American Journal of Tropical Medicine and Hygiène
Auteur(s)
Morizot  G., Delgiudice  P., Caumes  E., Laffitte  E., Marty  P., Dupuy  A., Sarfati  C., Hadj-Rabia  S., Darie  H., AS  L. E. Guern, Salah  A. B., Pratlong  F., Dedet  J. P., Grogl  M., Buffet  P. A.
ISSN
0002-9637 (Print)
Statut éditorial
Publié
Date de publication
01/2007
Volume
76
Numéro
1
Pages
48-52
Notes
Clinical Trial
Journal Article --- Old month value: Jan
Résumé
The efficacy of fluconazole was evaluated in 35 travelers with parasitologically proven imported Old World cutaneous leishmaniasis (CL). Leishmania major (mainly MON-25) was identified in 15 patients and strongly suspected given the transmission area in 12 of these patients. Daily oral fluconazole (200 mg/day for adults and 2.5 mg/kg/day for children) was prescribed for six weeks. Outcome definition was based on re-epithelialization rate at day 50. Of the 27 L. major-infected patients, 12 (44.4%) were cured. This cure rate is similar to the placebo cure rate from trials in L. major CL in which, as in the present report, the definition of outcome relied exclusively on re-epithelialization. These data question the assumption that oral fluconazole is consistently effective for treatment of CL caused by L. major.
Mots-clé
Adult Aged Aged, 80 and over Animals Antiparasitic Agents/adverse effects/*therapeutic use Child Child, Preschool *Evolution Female Fluconazole/adverse effects/*therapeutic use Humans Infant Leishmania/drug effects Leishmaniasis, Cutaneous/*drug therapy Male Middle Aged *Travel
Pubmed
Web of science
Création de la notice
25/01/2008 16:41
Dernière modification de la notice
20/08/2019 14:06
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