Mecanismes pathogeniques des maladies neurodegeneratives: l'exemple de la sclerose laterale amyotrophique. [Pathogenic mechanisms of neurodegenerative diseases: amyotrophic lateral sclerosis]
Details
Serval ID
serval:BIB_502671862A51
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Mecanismes pathogeniques des maladies neurodegeneratives: l'exemple de la sclerose laterale amyotrophique. [Pathogenic mechanisms of neurodegenerative diseases: amyotrophic lateral sclerosis]
Journal
Revue Médicale Suisse
ISSN
1660-9379 (Print)
Publication state
Published
Issued date
05/2006
Peer-reviewed
Oui
Volume
2
Number
64
Pages
1152-4, 1156-7
Notes
English Abstract Journal Article Review --- Old month value: May 3
Abstract
Since its description by Charcot in 1869, the mechanism underlying the characteristic selective degeneration and death of motor neurons in amyotrophic lateral sclerosis (ALS) has remained a mystery. There is no effective remedy for this progressive, fatal disorder. Modern genetics have now identified two genes, SODI and ALS2 as primary causes of the disease and has implicated others as potential contributors. These insights have enabled development of model systems to test hypotheses of disease mechanism and potential therapies. Along with errors in the handling of synaptic glutamate and the potential excitotoxic response that it provokes, these model systems underscore the involvement of non-neuronal cells in disease progression and provide new therapeutic strategies.
Keywords
Amyotrophic Lateral Sclerosis/*etiology Humans
Pubmed
Create date
25/01/2008 12:49
Last modification date
20/08/2019 14:06