The role of A-kinase anchoring proteins in cancer development.

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State: Public
Version: Author's accepted manuscript
License: Not specified
Serval ID
serval:BIB_4FCBC01F49D8
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
The role of A-kinase anchoring proteins in cancer development.
Journal
Cellular Signalling
Author(s)
Reggi E., Diviani D.
ISSN
1873-3913 (Electronic)
ISSN-L
0898-6568
Publication state
Published
Issued date
2017
Peer-reviewed
Oui
Volume
40
Pages
143-155
Language
english
Abstract
Cancer development is a multifactorial process resulting from the aberrant activation of multiple signaling pathways. It has become increasingly clear that the coordination of the signaling events leading to cancer formation and progression is under the control of macromolecular transduction complexes organized by scaffolding proteins. A-kinase anchoring proteins (AKAPs) constitute a family of scaffolding proteins involved in the spatio-temporal activation of pathways controlling cancer cell proliferation, cell survival, and invasion. Mutations or altered expression of AKAP coding genes results in unregulated signaling associated with oncogenesis, cancer maintenance, and metastasis. This review will focus on recent advances illustrating the role of AKAPs in cancer pathophysiology as well as on their potential as therapeutic targets.
Keywords
A-kinase anchoring protein (AKAP), Cancer, Cyclic AMP, Protein kinase A, Signal transduction
Pubmed
Web of science
Funding(s)
Swiss National Science Foundation / Projects
Create date
27/11/2017 17:16
Last modification date
17/09/2020 8:17
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