NLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production?

Details

Serval ID
serval:BIB_4F5B0BD7E548
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
NLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production?
Journal
Nature Reviews. Immunology
Author(s)
Tschopp J., Schroder K.
ISSN
1474-1741[electronic], 1474-1733[linking]
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
10
Number
3
Pages
210-215
Language
english
Abstract
The NLR family, pyrin domain-containing 3 (NLRP3) inflammasome is a multiprotein complex that activates caspase 1, leading to the processing and secretion of the pro-inflammatory cytokines interleukin-1beta (IL-1beta) and IL-18. The NLRP3 inflammasome is activated by a wide range of danger signals that derive not only from microorganisms but also from metabolic dysregulation. It is unclear how these highly varied stress signals can be detected by a single inflammasome. In this Opinion article, we review the different signalling pathways that have been proposed to engage the NLRP3 inflammasome and suggest a model in which one of the crucial elements for NLRP3 activation is the generation of reactive oxygen species (ROS).
Keywords
Animals, Anti-Inflammatory Agents/pharmacology, Antigen-Antibody Complex/immunology, Antigen-Antibody Complex/metabolism, Carrier Proteins/immunology, Carrier Proteins/metabolism, Humans, Inflammation/drug therapy, Inflammation/immunology, Interleukin-1/antagonists & inhibitors, Interleukin-1/immunology, Mice, Mice, Knockout, Reactive Oxygen Species/immunology, Reactive Oxygen Species/metabolism, Signal Transduction
Pubmed
Web of science
Create date
07/09/2010 15:38
Last modification date
20/08/2019 14:05
Usage data