Administration intra-vitréenne de liposomes pour la vectorisation de principes actifs [The use of liposomes as intravitreal drug delivery system].

Details

Serval ID
serval:BIB_4ED717C46031
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Administration intra-vitréenne de liposomes pour la vectorisation de principes actifs [The use of liposomes as intravitreal drug delivery system].
Journal
Journal Français D'ophtalmologie
Author(s)
Bejjani R.A., Jeanny J.C., Bochot A., Behar-Cohen F.
ISSN
0181-5512 (Print)
ISSN-L
0181-5512
Publication state
Published
Issued date
2003
Peer-reviewed
Oui
Volume
26
Number
9
Pages
981-985
Language
french
Notes
Publication types: English Abstract ; Journal Article ; ReviewPublication Status: ppublish
Abstract
Liposomes are vesicular lipidic systems allowing encapsulation of drugs. This article reviews the relevant issues in liposome structure (composition and size), and their influence on intravitreal pharmacokinetics. Liposome-mediated drug delivery to the posterior segment of the eye via intravitreal administration has been addressed by several authors and remains experimental. Liposomes have been used for intravitreal delivery of antibiotics, antivirals, antifungal drugs, antimetabolites, and cyclosporin. Encapsulation of these drugs within liposomes markedly increased their intravitreal half-life, and reduced their retinal toxicity. Liposomes have also shown an attractive potential for retinal gene transfer by intravitreal delivery of plasmids or oligonucleotides.
Keywords
Administration, Topical, Biological Availability, Blood-Retinal Barrier, Drug Delivery Systems/methods, Gene Transfer Techniques, Half-Life, Humans, Liposomes/administration & dosage, Liposomes/chemistry, Metabolic Clearance Rate, Vitreous Body/drug effects, Vitreous Body/metabolism
Pubmed
Web of science
Create date
19/11/2013 11:43
Last modification date
20/08/2019 14:04
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