PROPPINs and membrane fission in the endo-lysosomal system.

Details

Ressource 1Download: draft_NG4_AM11.pdf (1092.33 [Ko])
State: Public
Version: author
License: Not specified
Serval ID
serval:BIB_4E16AF4C34EC
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
PROPPINs and membrane fission in the endo-lysosomal system.
Journal
Biochemical Society transactions
Author(s)
Gopaldass N., Mayer A.
ISSN
1470-8752 (Electronic)
ISSN-L
0300-5127
Publication state
Published
Issued date
15/05/2024
Peer-reviewed
Oui
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
PROPPINs constitute a conserved protein family with multiple members being expressed in many eukaryotes. PROPPINs have mainly been investigated for their role in autophagy, where they co-operate with several core factors for autophagosome formation. Recently, novel functions of these proteins on endo-lysosomal compartments have emerged. PROPPINs support the division of these organelles and the formation of tubulo-vesicular cargo carriers that mediate protein exit from them, such as those generated by the Retromer coat. In both cases, PROPPINs provide membrane fission activity. Integrating information from yeast and human cells this review summarizes the most important molecular features that allow these proteins to facilitate membrane fission and thus provide a critical element to endo-lysosomal protein traffic.
Keywords
Retromer, WIPI proteins, autophagy, endosomes, lysosomes, protein sorting
Pubmed
Create date
16/05/2024 16:05
Last modification date
24/05/2024 7:11
Usage data