Peri-implant bone remodeling after total hip replacement combined with systemic alendronate treatment: a finite element analysis.

Details

Serval ID
serval:BIB_4CA0D8349F40
Type
Article: article from journal or magazin.
Collection
Publications
Title
Peri-implant bone remodeling after total hip replacement combined with systemic alendronate treatment: a finite element analysis.
Journal
Computer Methods in Biomechanics and Biomedical Engineering
Author(s)
Peter B., Ramaniraka N., Rakotomanana L.R., Zambelli P.Y., Pioletti D.P.
ISSN
1025-5842 (Print)
ISSN-L
1025-5842
Publication state
Published
Issued date
04/2004
Peer-reviewed
Oui
Volume
7
Number
2
Pages
73-78
Language
english
Notes
Publication types: Comparative Study ; Evaluation Studies ; Journal Article ; Validation Studies
Publication Status: ppublish
Abstract
In order to decrease the peri-implant bone loss during the life-time of the implant, oral use of anti-osteoporosis drugs (like bisphosphonates) has been suggested. In this study, bone remodeling parameters identified from clinical trials of alendronate were used to simulate the effect of those drugs used after total hip arthroplasty on the peri-implant bone density. Results of the simulation show that the oral administrated drugs increase bone density around the implant and decreases, at the same time, the micromovements between the implant and the surrounding bone tissue. Incorporation of drug effect in numerical studies of bone remodeling is a promising tool especially to predetermine safe bisphosphonate doses that could be used with orthopedic implants.
Keywords
Administration, Oral, Alendronate/administration & dosage, Arthroplasty, Replacement, Hip/adverse effects, Bone Density/drug effects, Bone Density/physiology, Bone Remodeling/drug effects, Bone Remodeling/physiology, Computer Simulation, Dose-Response Relationship, Drug, Drug Therapy, Computer-Assisted/methods, Equipment Failure Analysis/methods, Femur/drug effects, Femur/physiopathology, Finite Element Analysis, Hip Prosthesis/adverse effects, Humans, Models, Biological, Osteoporosis/etiology, Osteoporosis/physiopathology, Prosthesis Failure, Prosthesis-Related Infections/etiology, Prosthesis-Related Infections/physiopathology, Treatment Outcome
Pubmed
Create date
28/01/2008 13:29
Last modification date
20/08/2019 15:01
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