Genetic dissection of sodium and potassium transport along the aldosterone-sensitive distal nephron: Importance in the control of blood pressure and hypertension.

Details

Ressource 1Download: 5_23684652_Postprint.pdf (1456.21 [Ko])
State: Public
Version: Author's accepted manuscript
Serval ID
serval:BIB_4C555D266DE6
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Genetic dissection of sodium and potassium transport along the aldosterone-sensitive distal nephron: Importance in the control of blood pressure and hypertension.
Journal
Febs Letters
Author(s)
Rossier B.C., Staub O., Hummler E.
ISSN
1873-3468 (Electronic)
ISSN-L
0014-5793
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
587
Number
13
Pages
1929-1941
Language
english
Notes
Publication types: Journal Article ; pdf : Review
Abstract
In this review, we discuss genetic evidence supporting Guyton's hypothesis stating that blood pressure control is critically depending on fluid handling by the kidney. The review is focused on the genetic dissection of sodium and potassium transport in the distal nephron and the collecting duct that are the most important sites for the control of sodium and potassium balance by aldosterone and angiotensin II. Thanks to the study of Mendelian forms of hypertension and their corresponding transgenic mouse models, three main classes of diuretic receptors (furosemide, thiazide, amiloride) and the main components of the aldosterone- and angiotensin-dependent signaling pathways were molecularly identified over the past 20years. This will allow to design rational strategies for the treatment of hypertension and for the development of the next generation of diuretics.
Pubmed
Web of science
Open Access
Yes
Create date
13/06/2013 10:44
Last modification date
20/08/2019 15:00
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