Infectiologie sur mesure - 1.Immunogénétique des maladies infectieuses : premiers pas [Customised infectiology - Immunogenetics]

Details

Serval ID
serval:BIB_4C14150B4272
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Infectiologie sur mesure - 1.Immunogénétique des maladies infectieuses : premiers pas [Customised infectiology - Immunogenetics]
Journal
Revue medicale suisse
Author(s)
Neofytos D., Bibert S., Bochud P.Y.
ISSN
1660-9379 (Print)
ISSN-L
1660-9379
Publication state
Published
Issued date
10/04/2019
Peer-reviewed
Oui
Volume
15
Number
646
Pages
766-770
Language
french
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Recent discoveries in innate immunity together with improvements in the analysis of the human genome have led to the identification of factors that make certain individuals more susceptible to infections than other. We know understand why herpes simplex virus I, a virus with a minor burden in most individuals, is responsible for devastating encephalitis in children unable to detect primo-infection of neural cells. A growing number of patients are treated with immunosuppressive drugs in the field of oncology, organ transplantation and immunology. In such patients, opportunistic infections such invasive aspergillosis are clearly associated with genetic polymorphisms. Medical immune suppression represents a possible model for personalized approaches, in which infections could be prevented by individualized prophylactic strategies based on genetic testing.
Keywords
Aspergillosis/genetics, Aspergillosis/immunology, Aspergillosis/therapy, Child, Humans, Immunity, Innate, Immunogenetics, Immunosuppression, Opportunistic Infections/genetics, Opportunistic Infections/therapy
Pubmed
Create date
15/04/2019 16:33
Last modification date
20/08/2019 14:00
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