Sex differences in neurodevelopmental and common mental disorders examined from three epidemiological perspectives.

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State: Public
Version: Author's accepted manuscript
License: Not specified
Serval ID
serval:BIB_4B2D8931709E
Type
Article: article from journal or magazin.
Collection
Publications
Title
Sex differences in neurodevelopmental and common mental disorders examined from three epidemiological perspectives.
Journal
Psychiatry research
Author(s)
Tesic A., Rodgers S., Müller M., Wagner E.N., von Känel R., Castelao E., Strippoli M.F., Vandeleur C.L., Seifritz E., Preisig M., Ajdacic-Gross V.
ISSN
1872-7123 (Electronic)
ISSN-L
0165-1781
Publication state
Published
Issued date
08/2019
Peer-reviewed
Oui
Volume
278
Pages
213-217
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Sex differences in neurodevelopmental and common mental disorders are a ubiquitous, well-known, though poorly understood phenomenon. This study examined the issue from three epidemiological perspectives: congruence in age of onset, distribution of sex-ratios with respect to age of onset and similarity of comorbidity and risk factor patterns. The analysis was based on data from the population-based PsyCoLaus study (N = 4874, age 35-82 y). Congruence in age of onset and distribution of sex-ratios were examined with the Mann-Whitney test and cluster analysis. The similarity of comorbidity and risk factor patterns, which were represented by 35 variables, was assessed with the Jaccard coefficient and, after factor analysis, with Tucker's congruence coefficient. While age of onset parameters differed little by sex, the sex ratio varied markedly both in early and in late onset disorders. Moreover, the Jaccard coefficients for most disorders indicated that the similarity of comorbidity and further association patterns was low. Similarly, Tucker's congruence coefficient remained below the range of fair similarity in all factor combinations. In sum, sex differences in common mental disorders were impressively reflected by diverging sex ratios and comorbidity / risk factor patterns. This outcome supports the notion that most mental disorders need a sex-specific etiopathogenetic understanding.
Keywords
Adult, Age of Onset, Aged, Aged, 80 and over, Comorbidity, Female, Humans, Male, Mental Disorders/epidemiology, Middle Aged, Neurodevelopmental Disorders/epidemiology, Risk Factors, Sex Characteristics, Age of onset, Mental disorders, Neurodevelopmental disorders, Sex differences, Sex ratio, Similarity index
Pubmed
Web of science
Create date
25/06/2019 10:08
Last modification date
05/04/2020 6:20
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