Protein-protein interactions at the adrenergic receptors.

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State: Public
Version: author
Serval ID
serval:BIB_4AB2C5B53D6D
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Protein-protein interactions at the adrenergic receptors.
Journal
Current Drug Targets
Author(s)
Cotecchia S., Stanasila L., Diviani D.
ISSN
1873-5592 (Electronic)
ISSN-L
1389-4501
Publication state
Published
Issued date
2012
Volume
13
Number
1
Pages
15-27
Language
english
Abstract
The adrenergic receptors are among the best characterized G protein-coupled receptors (GPCRs) and knowledge on this receptor family has provided several important paradigms about GPCR function and regulation. One of the most recent paradigms initially supported by studies on adrenergic receptors is that both βarrestins and G proteincoupled receptors themselves can act as scaffolds binding a variety of proteins and this can result in growing complexity of the receptor-mediated cellular effects. In this review we will briefly summarize the main features of βarrestin binding to the adrenergic receptor subtypes and we will review more in detail the main proteins found to selectively interact with distinct AR subtype. At the end, we will review the main findings on oligomerization of the AR subtypes.
Keywords
Adrenergic receptor subtypes, signaling complexes, arrestins, receptor oligomerization
Pubmed
Web of science
Create date
15/02/2012 11:49
Last modification date
20/10/2020 10:08
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