Determinants for membrane association of the hepatitis C virus NS2 protease domain.

Details

Serval ID
serval:BIB_49965DC01ED0
Type
Article: article from journal or magazin.
Collection
Publications
Title
Determinants for membrane association of the hepatitis C virus NS2 protease domain.
Journal
Journal of Virology
Author(s)
Lange C.M., Bellecave P., Dao Thi V.L., Tran H.T., Penin F., Moradpour D., Gouttenoire J.
ISSN
1098-5514 (Electronic)
ISSN-L
0022-538X
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
88
Number
11
Pages
6519-6523
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.Publication Status: ppublish
Abstract
Hepatitis C virus (HCV) nonstructural protein 2 (NS2) is required for HCV polyprotein processing and particle assembly. It comprises an N-terminal membrane domain and a C-terminal, cytosolically oriented protease domain. Here, we demonstrate that the NS2 protease domain itself associates with cellular membranes. A single charged residue in the second α-helix of the NS2 protease domain is required for proper membrane association, NS2 protein stability, and efficient HCV polyprotein processing.
Pubmed
Web of science
Open Access
Yes
Create date
14/06/2014 15:08
Last modification date
20/08/2019 14:57
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