Peri-personal space encoding in patients with disorders of consciousness and cognitive-motor dissociation.

Details

Serval ID
serval:BIB_48D662A4017F
Type
Article: article from journal or magazin.
Collection
Publications
Title
Peri-personal space encoding in patients with disorders of consciousness and cognitive-motor dissociation.
Journal
NeuroImage. Clinical
Author(s)
Noel J.P., Chatelle C., Perdikis S., Jöhr J., Lopes Da Silva M., Ryvlin P., De Lucia M., Millán JDR, Diserens K., Serino A.
ISSN
2213-1582 (Electronic)
ISSN-L
2213-1582
Publication state
Published
Issued date
2019
Peer-reviewed
Oui
Volume
24
Pages
101940
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Behavioral assessments of consciousness based on overt command following cannot differentiate patients with disorders of consciousness (DOC) from those who demonstrate a dissociation between intent/awareness and motor capacity: cognitive motor dissociation (CMD). We argue that delineation of peri-personal space (PPS) - the multisensory-motor space immediately surrounding the body - may differentiate these patients due to its central role in mediating human-environment interactions, and putatively in scaffolding a minimal form of selfhood. In Experiment 1, we determined a normative physiological index of PPS by recording electrophysiological (EEG) responses to tactile, auditory, or audio-tactile stimulation at different distances (5 vs. 75 cm) in healthy volunteers (N = 19). Contrasts between paired (AT) and summed (A + T) responses demonstrated multisensory supra-additivity when AT stimuli were presented near, i.e., within the PPS, and highlighted somatosensory-motor sensors as electrodes of interest. In Experiment 2, we recorded EEG in patients behaviorally diagnosed as DOC or putative CMD (N = 17, 30 sessions). The PPS-measure developed in Experiment 1 was analyzed in relation with both standard clinical diagnosis (i.e., Coma Recovery Scale; CRS-R) and a measure of neural complexity associated with consciousness. Results demonstrated a significant correlation between the PPS measure and neural complexity, but not with the CRS-R, highlighting the added value of the physiological recordings. Further, multisensory processing in PPS was preserved in putative CMD but not in DOC patients. Together, the findings suggest that indexing PPS allows differentiating between groups of patients whom both show overt motor impairments (DOC and CMD) but putatively distinct levels of awareness or motor intent.
Keywords
Brain injury, Disorders of consciousness, Electroencephalography, Motor-cognitive dissociation, Multisensory, Peri-personal space
Pubmed
Web of science
Open Access
Yes
Create date
06/08/2019 17:24
Last modification date
12/01/2020 7:20
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