Dissection of genetic variation and evidence for pleiotropy in male pattern baldness.

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Version: Final published version
Serval ID
serval:BIB_48C4A35D6C35
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Dissection of genetic variation and evidence for pleiotropy in male pattern baldness.
Journal
Nature communications
Author(s)
Yap C.X., Sidorenko J., Wu Y., Kemper K.E., Yang J., Wray N.R., Robinson M.R., Visscher P.M.
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Publication state
Published
Issued date
20/12/2018
Peer-reviewed
Oui
Volume
9
Number
1
Pages
5407
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
Male pattern baldness (MPB) is a sex-limited, age-related, complex trait. We study MPB genetics in 205,327 European males from the UK Biobank. Here we show that MPB is strongly heritable and polygenic, with pedigree-heritability of 0.62 (SE = 0.03) estimated from close relatives, and SNP-heritability of 0.39 (SE = 0.01) from conventionally-unrelated males. We detect 624 near-independent genome-wide loci, contributing SNP-heritability of 0.25 (SE = 0.01), of which 26 X-chromosome loci explain 11.6%. Autosomal genetic variance is enriched for common variants and regions of lower linkage disequilibrium. We identify plausible genetic correlations between MPB and multiple sex-limited markers of earlier puberty, increased bone mineral density (r <sub>g</sub>  = 0.15) and pancreatic β-cell function (r <sub>g</sub>  = 0.12). Correlations with reproductive traits imply an effect on fitness, consistent with an estimated linear selection gradient of -0.018 per MPB standard deviation. Overall, we provide genetic insights into MPB: a phenotype of interest in its own right, with value as a model sex-limited, complex trait.
Keywords
Age Factors, Alopecia/genetics, Bone Density, Genetic Pleiotropy, Genetic Variation, Humans, Linkage Disequilibrium, Polymorphism, Single Nucleotide, United Kingdom
Pubmed
Web of science
Open Access
Yes
Create date
28/01/2019 10:23
Last modification date
20/08/2019 13:55
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