Dissection of genetic variation and evidence for pleiotropy in male pattern baldness.
Détails
Télécharger: s41467-018-07862-y.pdf (1096.10 [Ko])
Etat: Public
Version: Final published version
Etat: Public
Version: Final published version
ID Serval
serval:BIB_48C4A35D6C35
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Dissection of genetic variation and evidence for pleiotropy in male pattern baldness.
Périodique
Nature communications
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Statut éditorial
Publié
Date de publication
20/12/2018
Peer-reviewed
Oui
Volume
9
Numéro
1
Pages
5407
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Publication Status: epublish
Résumé
Male pattern baldness (MPB) is a sex-limited, age-related, complex trait. We study MPB genetics in 205,327 European males from the UK Biobank. Here we show that MPB is strongly heritable and polygenic, with pedigree-heritability of 0.62 (SE = 0.03) estimated from close relatives, and SNP-heritability of 0.39 (SE = 0.01) from conventionally-unrelated males. We detect 624 near-independent genome-wide loci, contributing SNP-heritability of 0.25 (SE = 0.01), of which 26 X-chromosome loci explain 11.6%. Autosomal genetic variance is enriched for common variants and regions of lower linkage disequilibrium. We identify plausible genetic correlations between MPB and multiple sex-limited markers of earlier puberty, increased bone mineral density (r <sub>g</sub> = 0.15) and pancreatic β-cell function (r <sub>g</sub> = 0.12). Correlations with reproductive traits imply an effect on fitness, consistent with an estimated linear selection gradient of -0.018 per MPB standard deviation. Overall, we provide genetic insights into MPB: a phenotype of interest in its own right, with value as a model sex-limited, complex trait.
Mots-clé
Age Factors, Alopecia/genetics, Bone Density, Genetic Pleiotropy, Genetic Variation, Humans, Linkage Disequilibrium, Polymorphism, Single Nucleotide, United Kingdom
Pubmed
Web of science
Open Access
Oui
Création de la notice
28/01/2019 10:23
Dernière modification de la notice
21/11/2022 8:19