The neurotransmitter basis of cognition: psychopharmacological activation studies using positron emission tomography.

Details

Serval ID
serval:BIB_47951538A3DF
Type
Article: article from journal or magazin.
Collection
Publications
Title
The neurotransmitter basis of cognition: psychopharmacological activation studies using positron emission tomography.
Journal
Ciba Foundation Symposium
Author(s)
Friston K.J., Grasby P.M., Frith C.D., Bench C.J., Dolan R.J., Cowen P.J., Liddle P.F., Frackowiak R.S.
ISSN
0300-5208 (Print)
ISSN-L
0300-5208
Publication state
Published
Issued date
1991
Volume
163
Pages
76-87; discussion 87-92
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
The neuromodulatory effect of manipulating monoaminergic receptor function was assessed by combining a psychological and a pharmacological activation during repeated positron emission tomographic (PET) scans. The effects of buspirone (a 5-HT1A receptor partial agonist) on changes in regional cerebral blood flow (rCBF) associated with free word recall were examined. A factorial design was used to demonstrate a significant interaction (changes in rCBF brought about by psychological activation which depend on drug administration) in the left parahippocampal region. This interaction was an attenuation of increases in local neuronal activity (rCBF) related to memory function. Buspirone-induced decreases in rCBF, independent of the memory effect, were seen in the left prefrontal and parietal cortices. We suggest that combined psychological and pharmacological activation is a way of measuring direct (main) drug effects and modulatory effects on neurotransmission associated with cognitive functions (interaction).
Keywords
Adult, Brain Mapping/methods, Buspirone/pharmacology, Cerebrovascular Circulation/drug effects, Cognition/drug effects, Cognition/physiology, Humans, Male, Memory/drug effects, Neurosecretory Systems/drug effects, Neurotransmitter Agents/physiology, Tomography, Emission-Computed
Pubmed
Web of science
Create date
06/10/2011 19:27
Last modification date
20/08/2019 13:53
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