Evaluation of serum myostatin and sclerostin levels in chronic spinal cord injured patients.

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State: Public
Version: Final published version
License: Not specified
Serval ID
serval:BIB_474831B6CFDD
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Evaluation of serum myostatin and sclerostin levels in chronic spinal cord injured patients.
Journal
Spinal Cord
Author(s)
Invernizzi M., Carda S., Rizzi M., Grana E., Squarzanti D.F., Cisari C., Molinari C., Renò F.
ISSN
1476-5624 (Electronic)
ISSN-L
1362-4393
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
53
Number
8
Pages
615-620
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
STUDY DESIGN: Case-control study.
OBJECTIVES: To assess serum myostatin levels, bone mineral density (BMD), appendicular skeletal muscle mass (ASMM) and serum sclerostin levels in chronic spinal cord injured (SCI) patients and healthy controls.
SETTING: SCI centre in Italy.
METHODS: Blood samples, whole-body bioelectrical impedance analysis and BMD measurement with the ultrasound technique at the calcaneus level were taken from patients suffering from chronic SCI (both motor complete and incomplete) and healthy control subjects.
RESULTS: A total of 28 SCI patients and 15 healthy controls were enrolled. Serum myostatin levels were statistically higher (P<0.01) in SCI patients compared with healthy controls. Similar results were found comparing both the motor complete and the motor incomplete SCI subgroups to healthy controls. Serum sclerostin was significantly higher in patients with SCI compared with healthy controls (P<0.01). BMD, stiffness and mean T-score values in SCI patients were significantly lower than those in healthy controls. Serum myostatin concentrations in the motor complete SCI subgroups correlated only with serum sclerostin levels (r(2)=0.42; P=0.001) and ASMM (r(2)=0.70; P=0.002) but not in healthy controls.
DISCUSSION: Serum myostatin and serum sclerostin are significantly higher in chronic SCI patients compared with healthy controls. They are potential biomarkers of muscle and bone modifications after SCI. This is the first study reporting an increase in serum myostatin in patients suffering from chronic SCI and a correlation with ASMM.
Keywords
Adolescent, Adult, Blood Chemical Analysis, Bone Morphogenetic Proteins/blood, Chronic Disease, Enzyme-Linked Immunosorbent Assay, Female, Genetic Markers, Humans, Male, Middle Aged, Movement Disorders/etiology, Myostatin/blood, Severity of Illness Index, Spinal Cord Injuries/blood, Spinal Cord Injuries/complications, Statistics as Topic, Statistics, Nonparametric, Young Adult
Pubmed
Web of science
Open Access
Yes
Create date
28/08/2015 17:32
Last modification date
15/07/2020 5:22
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