Multimodal Supervised Exercise Significantly Improves Walking Performances Without Changing Hemodynamic Parameters in Patients With Symptomatic Lower Extremity Peripheral Artery Disease.

Details

Serval ID
serval:BIB_465FEECE3FBE
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Multimodal Supervised Exercise Significantly Improves Walking Performances Without Changing Hemodynamic Parameters in Patients With Symptomatic Lower Extremity Peripheral Artery Disease.
Journal
Vascular and endovascular surgery
Author(s)
Calanca L., Lanzi S., Ney B., Berchtold A., Mazzolai L.
ISSN
1938-9116 (Electronic)
ISSN-L
1538-5744
Publication state
Published
Issued date
10/2020
Peer-reviewed
Oui
Volume
54
Number
7
Pages
605-611
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
We evaluated the outcome of multimodal supervised exercise training (SET) on walking performances and different hemodynamic parameters (ankle/toe-brachial index [ABI/TBI], and transcutaneous oxygen pressure [TcPO <sub>2</sub> ]) in patients with symptomatic lower extremity peripheral artery disease (PAD). Whether hemodynamic parameters predict walking performances at baseline and following SET was also investigated. Fontaine stage II PAD's patients following a 3-month SET were retrospectively included. Hemodynamic parameters and walking performances (pain-free [PFWD], maximal [MWD], and 6-minute [6MWD] walking distance) were measured in each patient. Eighty-five symptomatic PAD patients were included. Following SET, PFWD, MWD, and 6MWD significantly increased (+142%, +94%, +14%; respectively; P ≤ .001). Toe-brachial index significantly increased (MD: 0.04 ± 0.01; P = .02), whereas ABI and TcPO <sub>2</sub> did not change significantly. At baseline, patients with higher TBI and TcPO <sub>2</sub> performed significantly better (PFWD: β = 0.25, P = .01 for TBI; PFWD: β = 0.30, P = .005, and MWD: β = 0.22, P = .04, for TcPO <sub>2</sub> ). No significant relationship was observed at baseline between ABI and walking performances. Baseline values of hemodynamic parameters did not significantly correlate with changes in walking performances. Multimodal SET significantly improves walking performances. Following SET, no significant changes in ABI and TcPO <sub>2</sub> were observed. Toe-brachial index values significantly improved after SET. However, this increase was very modest and its clinical relevance remains questionable. Although baseline TBI and supine TcPO <sub>2</sub> values predict baseline walking performances, no association was found between baseline hemodynamic parameters and changes in walking performances following SET.
Keywords
Aged, Ankle Brachial Index, Blood Gas Monitoring, Transcutaneous, Exercise Therapy/methods, Exercise Tolerance, Female, Hemodynamics, Humans, Intermittent Claudication/diagnosis, Intermittent Claudication/physiopathology, Intermittent Claudication/therapy, Lower Extremity/blood supply, Male, Middle Aged, Muscle Strength, Peripheral Arterial Disease/diagnosis, Peripheral Arterial Disease/physiopathology, Peripheral Arterial Disease/therapy, Recovery of Function, Resistance Training, Retrospective Studies, Time Factors, Treatment Outcome, Walk Test, Walking, 6-minute walking test, intermittent claudication, multimodal training, vascular rehabilitation
Pubmed
Web of science
Create date
24/07/2020 13:57
Last modification date
02/02/2021 15:47
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