Insulin-like growth factor-I and C-reactive protein during pregnancy and maternal risk of non-epithelial ovarian cancer: a nested case-control study.

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State: Public
Version: author
Serval ID
serval:BIB_45FDB7F07C80
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Insulin-like growth factor-I and C-reactive protein during pregnancy and maternal risk of non-epithelial ovarian cancer: a nested case-control study.
Journal
Cancer Causes and Control
Author(s)
Toriola Adetunji T., Surcel Helja-Marja, Lundin Eva, Schock Helena, Grankvist Kjell, Pukkala Eero, Chen Tianhui, Toniolo Paolo, Lehtinen Matti, Zeleniuch-Jacquotte Anne, Lukanova Annekatrin
ISSN
1573-7225 (Electronic)
ISSN-L
0957-5243
Publication state
Published
Issued date
2011
Peer-reviewed
Oui
Volume
22
Number
11
Pages
1607-1611
Language
english
Abstract
BACKGROUND: Insulin-like growth factor-I (IGF-I) and C-reactive protein (CRP) may be positively associated with the risk of epithelial ovarian cancer (EOC) but no previous studies have investigated their associations with non-epithelial ovarian cancers (NEOC). METHODS: A case-control study was nested within the Finnish Maternity Cohort. Case subjects were 58 women diagnosed with sex cord-stromal tumors (SCST) and 30 with germ cell tumors (GCT) after recruitment. Control subjects (144 for SCST and 74 for GCT) were matched for age, parity, and date of blood donation of the index case. RESULTS: Doubling of IGF-I concentration was not related to maternal risk of either SCST (OR 0.97, 95% CI 0.58-1.62) or GCT (OR 1.13, 95% CI 0.51-2.51). Similarly, doubling of CRP concentrations was not related to maternal risk of either SCST (OR 1.10, 95% CI 0.85-1.43) or GCT (OR 0.93, 95% CI 0.68-1.28). CONCLUSIONS: Pre-diagnostic IGF-I and CRP concentrations during the first trimester of pregnancy were not associated with increased risk of NEOC in the mother. Risk factors for NEOC may differ from those of EOC.
Pubmed
Web of science
Create date
17/08/2011 17:06
Last modification date
20/08/2019 14:51
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