Effect of expiratory positive airway pressure on sleep disordered breathing.

Details

Serval ID
serval:BIB_45F2449D9E24
Type
Article: article from journal or magazin.
Collection
Publications
Title
Effect of expiratory positive airway pressure on sleep disordered breathing.
Journal
Sleep
Author(s)
Heinzer R., White D.P., Malhotra A., Lo Y.L., Dover L., Stevenson K.E., Jordan A.S.
ISSN
0161-8105
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
31
Number
3
Pages
429-432
Language
english
Abstract
STUDY OBJECTIVES: We sought to determine the effect of expiratory positive airway pressure on end expiratory lung volume (EELV) and sleep disordered breathing in obstructive sleep apnea patients. DESIGN: Observational physiology study PARTICIPANTS: We studied 10 OSA patients during sleep wearing a facial mask. We recorded 1 hour of NREM sleep without treatment (baseline) and 1 hour with 10 cm H2O EPAP in random order, while measuring EELV and breathing pattern. RESULTS: The mean EELV change between baseline and EPAP was only 13.3 mL (range 2-25 mL). Expiratory time was significantly increased with EPAP compared to baseline 2.64 +/- 0.54 vs 2.16 +/- 0.64 sec (P = 0.002). Total respiratory time was longer with EPAP than at baseline 4.44 +/- 1.47 sec vs 3.73 +/- 0.88 sec (P = 0.3), and minute ventilation was lower with EPAP vs baseline 7.9 +/- 4.17 L/min vs 9.05 +/- 2.85 L/min (P = 0.3). For baseline (no treatment) and EPAP respectively, the mean apnea+hypopnea index (AHI) was 62.6 +/- 28.7 and 56.8 +/- 30.3 events per hour (P = 0.4). CONCLUSION: In OSA patients during sleep, the application of 10 cm H2O EPAP led to prolongation of expiratory time with only marginal increases in FRC. These findings suggest important mechanisms exist to avoid hyperinflation during sleep.
Keywords
Adult, Airway Resistance/physiology, Body Mass Index, Expiratory Reserve Volume/physiology, Female, Functional Residual Capacity/physiology, Humans, Male, Middle Aged, Oxygen/blood, Polysomnography, Positive-Pressure Respiration, Sleep Apnea, Obstructive/diagnosis, Sleep Apnea, Obstructive/physiopathology, Tidal Volume/physiology
Pubmed
Web of science
Create date
02/10/2009 18:38
Last modification date
20/08/2019 14:51
Usage data