Immunoscintigraphy with biosynthetically-labeled 75Se-antibodies--I. Biodistribution of 75Se-monoclonal antibodies and of free radionuclide
Details
Serval ID
serval:BIB_45DF14866093
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Immunoscintigraphy with biosynthetically-labeled 75Se-antibodies--I. Biodistribution of 75Se-monoclonal antibodies and of free radionuclide
Journal
International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology
ISSN
0969-8051
0883-2897 (Print)
0883-2897 (Print)
Publication state
Published
Issued date
1990
Volume
17
Number
5
Pages
487-94
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, Non-U.S. Gov't
Abstract
Biosynthetically-radiolabeled MoAbs provide a tool to test whether structural modifications of the MoAbs influence the results of conventional immunoscintigraphy. When biosynthetically-labeled 75Se-MoAbs from the Mel-14 hybridoma were injected into mice with melanoma xenografts, the high tumor recovery supported the hypothesis of a structural advantage. The increased excretion of 75Se obtained by supplementing the diet of the mice with cold selenium did not reduce the tumor recovery, demonstrating an accumulation of the free radionuclide in normal tissue.
Keywords
Administration, Oral
Animals
Antibodies, Monoclonal/diagnostic use/*pharmacokinetics
Antigens, Neoplasm/*immunology
Humans
Isotope Labeling/methods
Melanoma/immunology/*metabolism/radionuclide imaging
Mice
Mice, Nude
Neoplasm Transplantation
Selenium/administration & dosage
Selenium Radioisotopes/diagnostic use/*pharmacokinetics
Tissue Distribution
Transplantation, Heterologous
Pubmed
Create date
25/01/2008 12:28
Last modification date
20/08/2019 14:50