Progressive decline of decision-making performances during multiple sclerosis.

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Serval ID
serval:BIB_454F8ACC0454
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Progressive decline of decision-making performances during multiple sclerosis.
Journal
Journal of the International Neuropsychological Society
Author(s)
Simioni S., Ruffieux C., Kleeberg J., Bruggimann L., du Pasquier R.A., Annoni J.M., Schluep M.
ISSN
1469-7661[electronic]
Publication state
Published
Issued date
2009
Peer-reviewed
Oui
Volume
15
Number
2
Pages
291-295
Language
english
Abstract
The purpose of this study was to evaluate longitudinally, using the Iowa Gambling Task (IGT), the dynamics of decision-making capacity at a two-year interval (median: 2.1 years) in a group of patients with multiple sclerosis (MS) (n = 70) and minor neurological disability [Expanded Disability Status Scale (EDSS) < or = 2.5 at baseline]. Cognition (memory, executive functions, attention), behavior, handicap, and perceived health status were also investigated. Standardized change scores [(score at retest-score at baseline)/standard deviation of baseline score] were computed. Results showed that IGT performances decreased from baseline to retest (from 0.3, SD = 0.4 to 0.1, SD = 0.3, p = .005). MS patients who worsened in the IGT were more likely to show a decreased perceived health status and emotional well-being (SEP-59; p = .05 for both). Relapsing rate, disability progression, cognitive, and behavioral changes were not associated with decreased IGT performances. In conclusion, decline in decision making can appear as an isolated deficit in MS.
Keywords
Adult, Decision Making, Disability Evaluation, Disease Progression, Female, Humans, Longitudinal Studies, Male, Middle Aged, Multiple Sclerosis, Neuropsychological Tests, Young Adult
Pubmed
Web of science
Open Access
Yes
Create date
29/05/2009 14:34
Last modification date
01/10/2019 7:17
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