Microdroplets in microfluidics: an evolving platform for discoveries in chemistry and biology.
Details
Serval ID
serval:BIB_44866C117AE0
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Microdroplets in microfluidics: an evolving platform for discoveries in chemistry and biology.
Journal
Angewandte Chemie
ISSN
1521-3773 (Electronic)
ISSN-L
1433-7851
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
49
Number
34
Pages
5846-5868
Language
english
Abstract
Microdroplets in microfluidics offer a great number of opportunities in chemical and biological research. They provide a compartment in which species or reactions can be isolated, they are monodisperse and therefore suitable for quantitative studies, they offer the possibility to work with extremely small volumes, single cells, or single molecules, and are suitable for high-throughput experiments. The aim of this Review is to show the importance of these features in enabling new experiments in biology and chemistry. The recent advances in device fabrication are highlighted as are the remaining technological challenges. Examples are presented to show how compartmentalization, monodispersity, single-molecule sensitivity, and high throughput have been exploited in experiments that would have been extremely difficult outside the microfluidics platform.
Keywords
Electrochemical Techniques, Gels/chemistry, Mass Spectrometry, Microfluidics/instrumentation, Microfluidics/methods, Polymerase Chain Reaction, Polymers/chemistry, Small Molecule Libraries/chemical synthesis, Small Molecule Libraries/chemistry, Spectrometry, Fluorescence, Spectrum Analysis, Raman, Surface-Active Agents/chemistry
Pubmed
Web of science
Create date
02/02/2017 8:12
Last modification date
20/08/2019 13:48