Skin Colonization by Staphylococcus aureus Precedes the Clinical Diagnosis of Atopic Dermatitis in Infancy.

Details

Serval ID
serval:BIB_42E090DFCA70
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Skin Colonization by Staphylococcus aureus Precedes the Clinical Diagnosis of Atopic Dermatitis in Infancy.
Journal
The Journal of investigative dermatology
Author(s)
Meylan P., Lang C., Mermoud S., Johannsen A., Norrenberg S., Hohl D., Vial Y., Prod'hom G., Greub G., Kypriotou M., Christen-Zaech S.
ISSN
1523-1747 (Electronic)
ISSN-L
0022-202X
Publication state
Published
Issued date
12/2017
Peer-reviewed
Oui
Volume
137
Number
12
Pages
2497-2504
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Atopic dermatitis (AD) has a well-established association with skin colonization or infection by Staphylococcus aureus, which can exacerbate the disease. However, a causal relationship between specific changes in skin colonization during the first years of life and AD development still remains unclear. In this prospective birth cohort study, we aimed to characterize the association between skin colonization and AD development in 149 white infants with or without a family history of atopy. We assessed infants clinically and collected axillary and antecubital fossa skin swabs for culture-based analysis at birth and at seven time points over the first 2 years of life. We found that at age 3 months, S. aureus was more prevalent on the skin of infants who developed AD later on. S. aureus prevalence was increased on infants' skin at the time of AD onset and also 2 months before it, when compared with age-matched, unaffected infants. Furthermore, at AD onset, infants testing positive for S. aureus were younger than uncolonized subjects. In conclusion, our results suggest that specific changes in early-life skin colonization may actively contribute to clinical AD onset in infancy.

Keywords
Dermatitis, Atopic/complications, Dermatitis, Atopic/drug therapy, Dermatitis, Atopic/microbiology, Eczema/complications, Eczema/drug therapy, Eczema/microbiology, Female, Follow-Up Studies, Humans, Infant, Infant, Newborn, Male, Prospective Studies, Skin/microbiology, Staphylococcal Infections/complications, Staphylococcal Infections/drug therapy, Staphylococcus aureus, Vagina/microbiology
Pubmed
Web of science
Create date
12/09/2017 14:59
Last modification date
20/08/2019 14:45
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