Corticotropin releasing factor activity of CRF 41 in normal man is potentiated by angiotensin II and vasopressin but not by desmopressin

Details

Serval ID
serval:BIB_42D7CADA81D6
Type
Article: article from journal or magazin.
Collection
Publications
Title
Corticotropin releasing factor activity of CRF 41 in normal man is potentiated by angiotensin II and vasopressin but not by desmopressin
Journal
Life Sciences
Author(s)
Gaillard  R. C., Riondel  A. M., Ling  N., Muller  A. F.
ISSN
0024-3205 (Print)
Publication state
Published
Issued date
1988
Volume
43
Number
23
Pages
1935-44
Notes
Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Abstract
Multiple hypothalamic factors seem to influence ACTH release. In vitro and/or in vivo animal models have shown that angiotensin II, vasopressin and some of its analogs are ACTH secretagogues capable of potentiating the corticotropin releasing activity of CRF41. Since these effects are controversial in man, we investigated in 3 groups of volunteers the corticotropin releasing activity of a 2h-infusion of angiotensin II (7 ng/kg/min), vasopressin (1 ng/kg/min) and desmopressin (1 ng/kg/min) given alone or in combination with a bolus injection of 100 micrograms CRF41 by measuring plasma concentrations of ACTH, cortisol, dehydroepiandrosterone and delta 4-androstenedione. Given alone angiotensin II and desmopressin had no significant effect in contrast to vasopressin which increased significantly the ACTH and steroid levels. Angiotensin II and vasopressin were both able to potentiate the corticotropin releasing activity of CRF41, whereas desmopressin was unable to produce such a potentiation. These results suggest that in man vasopressin and angiotensin II may well regulate the responsiveness of the pituitary-adrenal axis in various physiological or pathophysiological situations.
Keywords
Adrenocorticotropic Hormone/blood Adult Androstenedione/blood Angiotensin II/adverse effects/*pharmacology Corticotropin-Releasing Hormone/adverse effects/*pharmacology Deamino Arginine Vasopressin/adverse effects/*pharmacology Dehydroepiandrosterone/blood Drug Synergism Humans Hydrocortisone/blood Kinetics Male Vasopressins/adverse effects/*pharmacology
Pubmed
Web of science
Create date
15/02/2008 17:58
Last modification date
03/03/2018 16:39
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