Aminergic Signaling Controls Ovarian Dormancy in Drosophila.

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State: Public
Version: Final published version
Serval ID
serval:BIB_42B4FE08AC2D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Aminergic Signaling Controls Ovarian Dormancy in Drosophila.
Journal
Scientific reports
Author(s)
Andreatta G., Kyriacou C.P., Flatt T., Costa R.
ISSN
2045-2322 (Electronic)
ISSN-L
2045-2322
Publication state
Published
Issued date
01/02/2018
Peer-reviewed
Oui
Volume
8
Number
1
Pages
2030
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
In response to adverse environmental conditions many organisms from nematodes to mammals deploy a dormancy strategy, causing states of developmental or reproductive arrest that enhance somatic maintenance and survival ability at the expense of growth or reproduction. Dormancy regulation has been studied in C. elegans and in several insects, but how neurosensory mechanisms act to relay environmental cues to the endocrine system in order to induce dormancy remains unclear. Here we examine this fundamental question by genetically manipulating aminergic neurotransmitter signaling in Drosophila melanogaster. We find that both serotonin and dopamine enhance adult ovarian dormancy, while the downregulation of their respective signaling pathways in endocrine cells or tissues (insulin producing cells, fat body, corpus allatum) reduces dormancy. In contrast, octopamine signaling antagonizes dormancy. Our findings enhance our understanding of the ability of organisms to cope with unfavorable environments and illuminate some of the relevant signaling pathways.
Keywords
Animals, Dopamine/metabolism, Drosophila, Endocrine Cells/metabolism, Female, Octopamine/metabolism, Ovary/growth & development, Ovary/metabolism, Serotonin/metabolism, Signal Transduction
Pubmed
Web of science
Open Access
Yes
Create date
22/02/2018 15:52
Last modification date
20/08/2019 13:45
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