Orodigital pemphigus vulgaris : a pathogenic role of anti-desmoglein-3 autoantibodies in pemphigus paronychia?
Details
Serval ID
serval:BIB_42A1166386FD
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Orodigital pemphigus vulgaris : a pathogenic role of anti-desmoglein-3 autoantibodies in pemphigus paronychia?
Journal
Dermatology
ISSN
1018-8665
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
217
Number
4
Pages
337-339
Language
english
Abstract
Paronychia is a rare complication of pemphigus vulgaris (PV), and the immunological profile of patients with digital disease has not been assessed so far. We report 2 cases of PV with oral mucosa and periungual involvement, who had high titers of anti- desmoglein (Dsg)-3 circulating antibodies. These observations raise the possibility that expression of Dsg-1 and Dsg-3 in distinct areas of periungual skin is disease specific and that anti-Dsg-3 antibodies alone may have an as yet unrecognized importance for the development of paronychia in PV.
Keywords
Aged, Autoantibodies/blood, Biological Markers/blood, Desmoglein 1/immunology, Desmoglein 3/immunology, Enzyme-Linked Immunosorbent Assay, Female, Fingers, Humans, Middle Aged, Mouth Diseases/immunology, Mouth Diseases/pathology, Mouth Mucosa/pathology, Paronychia/immunology, Pemphigus/immunology, Pemphigus/pathology, Toes
Pubmed
Web of science
Create date
15/10/2009 9:06
Last modification date
20/08/2019 14:45