Differential expression of triiodothyronine receptors in schwannoma and neurofibroma: role of Schwann cell-axon interaction.

Details

Serval ID
serval:BIB_41DE9DDD6287
Type
Article: article from journal or magazin.
Collection
Publications
Title
Differential expression of triiodothyronine receptors in schwannoma and neurofibroma: role of Schwann cell-axon interaction.
Journal
Acta neuropathologica
Author(s)
Walter I.B., Deruaz J.P., de Tribolet N.
ISSN
0001-6322
Publication state
Published
Issued date
1995
Peer-reviewed
Oui
Volume
90
Number
2
Pages
142-149
Language
english
Abstract
Regulation of gene expression in Schwann cells may be determined, at least in part, by the interaction of these cells with axons. Two peripheral nerve tumors, neurofibroma and schwannoma, represent good tools for studying Schwann cell activity in the presence or absence of axon action. In the present work we studied the expression of triiodothyronine receptors (T3R) by Schwann cells in these two tumors and also in adult normal sciatic nerve. Confirming the results of the histological examination, immunostaining of the neurofilaments showed the presence of fascicles or scattered axons in all neurofibroma sections studied. In these neurofibromas, Schwann cells did not express T3R immunoreactivity. Furthermore, in adult normal sciatic nerve, Schwann cells which ensheathed axons were devoid of any T3R expression. In contrast, in schwannoma, the complete absence of axons was demonstrated by the lack of neurofilament immunostaining. Here, Schwann cells deprived of axonal interaction displayed clear T3R immunoreactivity. In schwannoma cell cultures, Schwann cells continued to express T3R, even in cultures treated with medium that had been conditioned with rat sensory neurons. On the basis of these results, we suggest that, beside the possible regulatory mechanisms for T3R, the synthesis of T3R is regulated, at least in part, by Schwann cell-axon interaction.
Keywords
Animals, Autopsy, Axons, Biopsy, Blotting, Western, Cells, Cultured, Immunohistochemistry, Neurilemmoma, Neurofibroma, Rats, Rats, Inbred Strains, Receptors, Thyroid Hormone, Schwann Cells, Sciatic Nerve
Pubmed
Web of science
Create date
26/03/2009 12:22
Last modification date
20/08/2019 14:43
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