Major coagulation disorders when using aprotinin--observations on a case

Details

Serval ID
serval:BIB_41D8FF7DCE08
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Title
Major coagulation disorders when using aprotinin--observations on a case
Journal
Thoracic and Cardiovascular Surgeon
Author(s)
Gersbach  P., Lammle  B., Schupbach  P., Muhlemann  W., Althaus  U.
ISSN
0171-6425 (Print)
Publication state
Published
Issued date
08/1991
Volume
39
Number
4
Pages
196-8
Notes
Case Reports
Journal Article --- Old month value: Aug
Abstract
Intraoperative application of the proteinase inhibitor aprotinin allows to drastically reduce blood loss during and after cardiopulmonary bypass operation. The side effects of this therapy (if any) have not been systematically registered and a possible interaction with heparin is not excluded. Such an interaction seems to have occurred in one of our patients. He developed a resistance to heparin shortly after prophylactic administration of aprotinin and maintained it for about one hour after discontinuation of the aprotinin. Prophylactic and therapeutic implications of this observation are briefly exposed.
Keywords
Aged Aprotinin/*adverse effects Blood Coagulation Disorders/*chemically induced Cardiac Surgical Procedures Heparin/administration & dosage Humans Male Postoperative Complications/chemically induced
Pubmed
Web of science
Create date
28/01/2008 10:17
Last modification date
20/08/2019 14:42
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