Perturbed rhythmic activation of signaling pathways in mice deficient for Sterol Carrier Protein 2-dependent diurnal lipid transport and metabolism.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_41D0E57B56E2
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Perturbed rhythmic activation of signaling pathways in mice deficient for Sterol Carrier Protein 2-dependent diurnal lipid transport and metabolism.
Journal
Scientific reports
Author(s)
Jouffe C., Gobet C., Martin E., Métairon S., Morin-Rivron D., Masoodi M., Gachon F.
ISSN
2045-2322 (Electronic)
ISSN-L
2045-2322
Publication state
Published
Issued date
21/04/2016
Peer-reviewed
Oui
Volume
6
Pages
24631
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
Through evolution, most of the living species have acquired a time keeping system to anticipate daily changes caused by the rotation of the Earth. In all of the systems this pacemaker is based on a molecular transcriptional/translational negative feedback loop able to generate rhythmic gene expression with a period close to 24 hours. Recent evidences suggest that post-transcriptional regulations activated mostly by systemic cues play a fundamental role in the process, fine tuning the time keeping system and linking it to animal physiology. Among these signals, we consider the role of lipid transport and metabolism regulated by SCP2. Mice harboring a deletion of the Scp2 locus present a modulated diurnal accumulation of lipids in the liver and a perturbed activation of several signaling pathways including PPARα, SREBP, LRH-1, TORC1 and its upstream regulators. This defect in signaling pathways activation feedbacks upon the clock by lengthening the circadian period of animals through post-translational regulation of core clock regulators, showing that rhythmic lipid transport is a major player in the establishment of rhythmic mRNA and protein expression landscape.
Keywords
Animals, Carrier Proteins/genetics, Carrier Proteins/metabolism, Circadian Clocks, Circadian Rhythm/genetics, Cluster Analysis, Gene Deletion, Gene Expression Profiling, Gene Expression Regulation, Lipid Metabolism, Male, Metabolic Networks and Pathways, Mice, Mice, Knockout, Protein Processing, Post-Translational, Signal Transduction
Pubmed
Open Access
Yes
Create date
10/05/2016 17:55
Last modification date
30/04/2021 6:09
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