Retroviral Integration Site Selection

Details

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State: Public
Version: Final published version
Serval ID
serval:BIB_41B16921A1E4
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Retroviral Integration Site Selection
Journal
Viruses-Basel
Author(s)
Desfarges S., Ciuffi A.
ISSN
1999-4915
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
2
Number
1
Pages
111-130
Language
english
Notes
Publication type : Review
Abstract
The stable insertion of a copy of their genome into the host cell genome is an essential step of the life cycle of retroviruses. The site of viral DNA integration, mediated by the viral-encoded integrase enzyme, has important consequences for both the virus and the host cell. The analysis of retroviral integration site distribution was facilitated by the availability of the human genome sequence, revealing the non-random feature of integration site selection and identifying different favored and disfavored genomic locations for individual retroviruses. This review will summarize the current knowledge about retroviral differences in their integration site preferences as well as the mechanisms involved in this process.
Keywords
retrovirus, integration, site selection, integrase, HIV, LEDGF, LEDGF/p75, PSIP1, lentivirus, transcription, HUMAN-IMMUNODEFICIENCY-VIRUS, MURINE LEUKEMIA-VIRUS, IN-VITRO INTEGRATION, GENOME-WIDE ANALYSIS, RNA-POLYMERASE-II, CD4(+) T-CELLS, HIV-1 INTEGRATION, DNA INTEGRATION, GENE-THERAPY, TYPE-1 INTEGRASE
Web of science
Open Access
Yes
Create date
27/01/2010 17:24
Last modification date
20/08/2019 13:42
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