Emphysème pulmonaire: mécanismes et nouvelles perspectives thérapeutiques [Pulmonary emphysema: mechanisms and therapeutic perspectives]

Details

Serval ID
serval:BIB_41AAE5CBFC1C
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Emphysème pulmonaire: mécanismes et nouvelles perspectives thérapeutiques [Pulmonary emphysema: mechanisms and therapeutic perspectives]
Journal
Revue Médicale Suisse
Author(s)
Egger B., Aubert J.D.
ISSN
1660-9379
Publication state
Published
Issued date
2005
Volume
1
Number
41
Pages
2665-2672
Language
french
Notes
Publication types: English Abstract ; Journal Article ; Review
Abstract
Emphysema is one of the components of chronic obstructive pulmonary disease beside the bronchial, vascular and systemic parts. The pathogenesis involves an inflammatory process (macrophages, neutrophiles and lymphocytes), but also an imbalance between proteases-anti-proteases and the oxidative stress by the formation of oxygen radicals. On the therapeutic level, these physiopathological pathways are the rational basis to the progressive use of antioxidants (mainly N-acetylcysteine) or, for the moment at an experimental level, of anti-proteases (inhibitors of serine proteases, cysteine proteases and the matrix metalloproteases). To reach the secondary lobule, site of the emphysema, the inhaled future treatments will have to be constituted of small particles, as in cigarette smoke, in order to distribute into the most homogeneous way the affected lung.
Keywords
Humans, Pulmonary Emphysema
Pubmed
Create date
21/01/2008 13:54
Last modification date
20/08/2019 14:42
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