Controlling complexity: the clinical relevance of mouse complex genetics.

Details

Serval ID
serval:BIB_419668E1C8F5
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Controlling complexity: the clinical relevance of mouse complex genetics.
Journal
European Journal of Human Genetics
Author(s)
Schughart K., Libert C., Kas M.J., Kas M.J.
Working group(s)
SYSGENET consortium
Contributor(s)
Andreux P., Aransay AM., Auwerx J., Balling R., Banerjee S., Bezerianos A., Bragonzi AD., Brockmann GA., Brown S., Campbell-Tofte J., Cendelin J., Chatziioannou A., Chen D., Crusio W., Dimitrakopoulou K., Falcon JM., Forejt J., Franken P., Fröhlich LF., Herault Y., Hovatta I., Iraqi FA., Jansen RC., Kaczmarek L., Kas M., Knapska E., Koks S., Kolisis F., Korostynski M., Lammert F., Lehrach H., Lengeling A., Libert C., Montagutelli X., Morahan G., Mott R., Panthier JJ., Przewlocki R., Ranki A., Santos J., Severcan F., Schalkwyk L., Schughart K., Smit AB., Terasmaa A., Vasar E., Zatloukal K.
ISSN
1476-5438 (Electronic)
ISSN-L
1018-4813
Publication state
Published
Issued date
2013
Volume
21
Number
11
Pages
1191-1196
Language
english
Notes
h
Abstract
Experimental animal models are essential to obtain basic knowledge of the underlying biological mechanisms in human diseases. Here, we review major contributions to biomedical research and discoveries that were obtained in the mouse model by using forward genetics approaches and that provided key insights into the biology of human diseases and paved the way for the development of novel therapeutic approaches.
Keywords
Animals, Biomedical Research, Humans, Mice, Models, Animal, Reverse Genetics
Pubmed
Web of science
Open Access
Yes
Create date
30/06/2015 9:47
Last modification date
20/08/2019 14:42
Usage data