A subgroup of malignant fibrous histiocytomas is associated with genetic changes similar to those of well-differentiated liposarcomas
Details
Serval ID
serval:BIB_418E18659A0D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A subgroup of malignant fibrous histiocytomas is associated with genetic changes similar to those of well-differentiated liposarcomas
Journal
Cancer Genetics and Cytogenetics
ISSN
0165-4608 (Print)
Publication state
Published
Issued date
2002
Volume
139
Number
1
Pages
24-29
Notes
PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't
Abstract
Increasing clinical and pathological evidence suggests that malignant fibrous histiocytomas (MFH) comprise a heterogeneous tumor group. In a series of 108 MFH tested by comparative genomic hybridization, we found in 22 tumors high-level coamplification of the 12q14 approximately q15 chromosome region with other loci, a genetics strongly reminiscent of what has been observed for well-differentiated liposarcomas. Nevertheless, these MFH differ from liposarcomas by a high recurrence of coamplified partners because coamplified loci were seen at 1p32 in nine cases, 6q23 in seven cases, and 12q24 in six cases. The same recurrence was observed in a series of dedifferentiated liposarcomas, but not in a series of well-differentiated liposarcomas. These observations demonstrate that a subgroup of MFH share a genetic partner very similar to that observed in liposarcomas, and suggest that the undifferentiated status of these tumors is closely related to the amplifications of specific chromosome loci
Keywords
Allelic Imbalance/Cell Differentiation/Chromosome Mapping/Chromosomes,Human,Pair 1/Chromosomes,Human,Pair 12/Chromosomes,Human,Pair 6/Histiocytoma,Benign Fibrous/genetics/Pathology/Humans/In Situ Hybridization,Fluorescence/Liposarcoma/Nucleic Acid Hybridization
Pubmed
Web of science
Create date
29/01/2008 18:33
Last modification date
20/08/2019 13:42