MOBP-specific cellular immune responses are weaker than MOG-specific cellular immune responses in patients with multiple sclerosis and healthy subjects.

Details

Serval ID
serval:BIB_4187CB3E957E
Type
Article: article from journal or magazin.
Collection
Publications
Title
MOBP-specific cellular immune responses are weaker than MOG-specific cellular immune responses in patients with multiple sclerosis and healthy subjects.
Journal
Neurological Sciences
Author(s)
Jilek S., Schluep M., Pantaleo G., Du Pasquier R.A.
ISSN
1590-3478 (Electronic)
ISSN-L
1590-1874
Publication state
Published
Issued date
2013
Volume
34
Number
4
Pages
539-543
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish. PDF type: Brief Communication
Abstract
Multiple sclerosis (MS) is an inflammatory and demyelinating disease of the central nervous system (CNS). Myelin oligodendrocyte glycoprotein (MOG) and myelin oligodendrocyte basic protein (MOBP) were both shown to be highly encephalitogenic in animal models of MS. In contrast, the association of MOG- and MOBP-specific humoral or cellular immune responses and MS in humans is far less established. In this study, we sought to analyse MOG- and MOBP-specific T-cell responses in a large cohort of patients with various stages of the disease. Patients with other neurological diseases and healthy subjects were enrolled to serve as control study subjects. We determined the proliferation and the secretion of IFN-γ secretion in our cohort. We found that MOG-specific T-cell responses were higher and more frequent as compared to MOBP-specific ones. However, both MS patients and control study subjects had similar myelin-specific T-cell responses at the periphery, thus calling for more precise studies at CNS level.
Pubmed
Web of science
Create date
08/04/2013 15:51
Last modification date
03/03/2018 16:33
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