MOBP-specific cellular immune responses are weaker than MOG-specific cellular immune responses in patients with multiple sclerosis and healthy subjects.

Détails

ID Serval
serval:BIB_4187CB3E957E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
MOBP-specific cellular immune responses are weaker than MOG-specific cellular immune responses in patients with multiple sclerosis and healthy subjects.
Périodique
Neurological Sciences
Auteur(s)
Jilek S., Schluep M., Pantaleo G., Du Pasquier R.A.
ISSN
1590-3478 (Electronic)
ISSN-L
1590-1874
Statut éditorial
Publié
Date de publication
2013
Volume
34
Numéro
4
Pages
539-543
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish. PDF type: Brief Communication
Résumé
Multiple sclerosis (MS) is an inflammatory and demyelinating disease of the central nervous system (CNS). Myelin oligodendrocyte glycoprotein (MOG) and myelin oligodendrocyte basic protein (MOBP) were both shown to be highly encephalitogenic in animal models of MS. In contrast, the association of MOG- and MOBP-specific humoral or cellular immune responses and MS in humans is far less established. In this study, we sought to analyse MOG- and MOBP-specific T-cell responses in a large cohort of patients with various stages of the disease. Patients with other neurological diseases and healthy subjects were enrolled to serve as control study subjects. We determined the proliferation and the secretion of IFN-γ secretion in our cohort. We found that MOG-specific T-cell responses were higher and more frequent as compared to MOBP-specific ones. However, both MS patients and control study subjects had similar myelin-specific T-cell responses at the periphery, thus calling for more precise studies at CNS level.
Pubmed
Web of science
Création de la notice
08/04/2013 15:51
Dernière modification de la notice
03/03/2018 16:33
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