Organ-specific lymphatic vasculature: From development to pathophysiology.

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Version: Final published version
License: CC BY-NC-SA 4.0
Serval ID
serval:BIB_41205D392493
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Organ-specific lymphatic vasculature: From development to pathophysiology.
Journal
The Journal of experimental medicine
Author(s)
Petrova T.V., Koh G.Y.
ISSN
1540-9538 (Electronic)
ISSN-L
0022-1007
Publication state
Published
Issued date
02/01/2018
Peer-reviewed
Oui
Volume
215
Number
1
Pages
35-49
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
Recent discoveries of novel functions and diverse origins of lymphatic vessels have drastically changed our view of lymphatic vasculature. Traditionally regarded as passive conduits for fluid and immune cells, lymphatic vessels now emerge as active, tissue-specific players in major physiological and pathophysiological processes. Lymphatic vessels show remarkable plasticity and heterogeneity, reflecting their functional specialization to control the tissue microenvironment. Moreover, alternative developmental origins of lymphatic endothelial cells in some organs may contribute to the diversity of their functions in adult tissues. This review aims to summarize the most recent findings of organotypic differentiation of lymphatic endothelial cells in terms of their distinct (patho)physiological functions in skin, lymph nodes, small intestine, brain, and eye. We discuss recent advances in our understanding of the heterogeneity of lymphatic vessels with respect to the organ-specific functional and molecular specialization of lymphatic endothelium, such as the hybrid blood-lymphatic identity of Schlemm's canal, functions of intestinal lymphatics in dietary fat uptake, and discovery of meningeal lymphatic vasculature and perivascular brain lymphatic endothelial cells.
Keywords
Animals, Endothelial Cells/metabolism, Humans, Lymphangiogenesis, Lymphatic Vessels/physiology, Lymphatic Vessels/physiopathology, Organ Specificity, Signal Transduction, Tissue Engineering
Pubmed
Web of science
Open Access
Yes
Create date
11/01/2018 19:52
Last modification date
29/05/2019 7:08
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