Folate intake and squamous-cell carcinoma of the oesophagus in Italian and Swiss men

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It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_40C8D07C755A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Folate intake and squamous-cell carcinoma of the oesophagus in Italian and Swiss men
Journal
Annals of Oncology
Author(s)
Galeone  Carlotta, Pelucchi  Claudio, Levi  Fabio, Negri  Eva, Talamini  Renato, Franceschi  Silvia, La Vecchia  Carlo
ISSN
0923-7534
Publication state
Published
Issued date
2006
Volume
17
Number
3
Pages
521-525
Notes
SAPHIRID:50200
Abstract
BACKGROUND: Dietary folate has been inversely related to the risk of several cancers. However, studies on the role of dietary folate in oesophageal cancer are scanty. PATIENTS AND METHODS: Using data from a multicentric case-control study conducted in Italy and Switzerland between 1992 and 1999, we investigated the association between dietary folate intake and oesophageal squamous-cell carcinoma (OSCC) among 351 men with incident, histologically confirmed OSCC and 875 hospital controls admitted for acute, non-neoplastic conditions, unrelated to alcohol and smoking consumption. Intake of folate and other nutrients was computed from a validated food frequency questionnaire. RESULTS: The multivariate odds ratios (ORs) of OSCC were 0.68 (95% confidence intervals, CI: 0.46-1.00) for the highest versus the lowest tertile of folate intake, and 0.84 (95% CI: 0.72-0.99) for an increment of folate intake equal to a standard deviation (98 microg/day). The inverse relation was somewhat stronger in strata of high methionine, vitamin B6 and alcohol intake, and did not vary substantially according to age and smoking habits. CONCLUSION: Dietary folate was inversely related to OSCC risk in this population with high alcohol consumption and infrequent use of supplements and multivitamins. [Authors]
Keywords
Carcinoma, Squamous Cell , Esophageal Neoplasms , Folic Acid , Men
Pubmed
Web of science
Open Access
Yes
Create date
04/03/2008 14:58
Last modification date
25/09/2019 6:09
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