Editing through multiple bonds: threonine detection.

Details

Serval ID
serval:BIB_40953A0A2136
Type
Article: article from journal or magazin.
Collection
Publications
Title
Editing through multiple bonds: threonine detection.
Journal
Magnetic Resonance in Medicine
Author(s)
Marjanska M., Henry P.G., Uğurbil K., Gruetter R.
ISSN
0740-3194 (Print)
ISSN-L
0740-3194
Publication state
Published
Issued date
2008
Volume
59
Number
2
Pages
245-251
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.Publication Status: ppublish
Abstract
In in vivo (1)H spectroscopy, the signal at 1.32 ppm is usually assigned to lactate. This resonance position is shared with threonine at physiological pH. The similarity of spectral patterns of lactate and threonine renders the separate measurement of either threonine or lactate without and even with editing technically challenging. In this study, the threonine signal was detected using a single-shot multiple-bond editing technique and quantified in vivo in both rat and human brains. A threonine concentration was estimated at 0.8 +/- 0.3 mM (mean +/- SD, n = 6) in the rat brain and at approximately 0.33 mM in the human brain.
Keywords
Animals, Brain/metabolism, Humans, Hydrogen-Ion Concentration, Lactates/metabolism, Magnetic Resonance Spectroscopy/methods, Male, Phantoms, Imaging, Rats, Rats, Sprague-Dawley, Reproducibility of Results, Threonine/metabolism
Pubmed
Web of science
Open Access
Yes
Create date
04/08/2010 16:28
Last modification date
08/05/2019 17:37
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