Secretory immunoglobulin A: well beyond immune exclusion at mucosal surfaces.

Details

Serval ID
serval:BIB_407F9DD78498
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Secretory immunoglobulin A: well beyond immune exclusion at mucosal surfaces.
Journal
Immunopharmacology and Immunotoxicology
Author(s)
Corthésy Blaise
ISSN
1532-2513[electronic]
Publication state
Published
Issued date
2009
Volume
31
Number
2
Pages
174-179
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish
Abstract
At mucosal surfaces, secretory IgA (SIgA) antibodies serve as the first line of defense against microorganisms through a mechanism called immune exclusion that prevents interaction of neutralized antigens with the epithelium. In addition, SIgA plays a role in the immune balance of the epithelial barrier through selective adhesion to M cells in intestinal Peyer's patches. This mediates the transepithelial retro-transport of the antibody and associated antigens from the intestinal lumen to underlying gut-associated organized lymphoid tissue. In Peyer's patches, SIgA-based immune complexes are internalized by underlying antigen-presenting cells, leaving the antigen with masked epitopes, a form that limits the risk of overwhelming the local immune protection system with danger signals. This translates into the onset of mucosal and systemic responses associated with production of anti-inflammatory cytokines and limited activation of antigen-presenting cells. In the gastrointestinal tract, SIgA exhibits thus properties of a neutralizing agent (immune exclusion) and of an immunopotentiator inducing effector immune responses in a noninflammatory context favorable to preserve local homeostasis.
Pubmed
Web of science
Create date
26/01/2010 16:55
Last modification date
03/03/2018 16:28
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